Yeast base excision repair: Interconnections and networks
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Cited by (34)
Base excision repair and nucleotide excision repair
2021, Genome Stability: From Virus to Human ApplicationRepair of Oxidative DNA Damage in Saccharomyces cerevisiae
2017, DNA RepairCitation Excerpt :Arrest in the progression of cell cycle provides sufficient time for the damage repair process. The presence of diverse repair pathways ensures that a backup system gets activated in case the primary pathway is perturbed [26]. Genes involved in the BER pathway show synergistic interactions with genes involved in other DNA repair pathways such as NER, MMR, HR, and TLS indicating the redundancy that exists between pathways for the repair of oxidative DNA damage [27,28].
Base Excision Repair and Nucleotide Excision Repair
2016, Genome Stability: From Virus to Human ApplicationCytotoxic mechanism of Piper gaudichaudianum Kunth essential oil and its major compound nerolidol
2013, Food and Chemical ToxicologyCitation Excerpt :Nerolidol induced cytotoxicity to ntg1Δ, ntg1Δntg2Δ, and ntg1Δntg2Δapn1Δ mutants increased compared to the isogenic SJR751 (Fig. 3B), as did the cytotoxicity in the single mutant apn1Δ in relation to the isogenic wild-type BY4741 strain (Fig. 3B and Fig. 3C). The Ntg1 and Ntg2 proteins are DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase, respectively, and the Apn1 protein is a major apurinic/apyrimidinic endonuclease with 3′-repair diesterase action (Boiteux and Guillet, 2004; Doetsch et al., 2001). The rad1Δ and rad10Δ strains, which lack the 5′- and 3′-endonucleases of NER (Prakash and Prakash, 2000), showed an intermediate sensitivity to P. gaudichaudianum essential oil (Fig. 4A).
Yap1: A DNA damage responder in Saccharomyces cerevisiae
2012, Mechanisms of Ageing and DevelopmentCitation Excerpt :In humans, recent studies have shown that defects in base excision repair and/or aberrant repair of oxidative DNA damage could contribute to tumorigenesis (Kryston et al., 2011; Nemec et al., 2010). Elucidation of oxidative DNA damage signaling is not a straightforward task since oxidative modifications of DNA are efficiently repaired by base excision repair enzymes with overlapping specificities (Doetsch et al., 2001). However, previous studies from our group have demonstrated that DNA damage itself causes increases in cellular ROS (Evert et al., 2004; Salmon et al., 2004; Rowe et al., 2008).
HNO induces DNA deletions in the yeast S. cerevisiae
2008, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis