HAMLET kills tumor cells by an apoptosis-like mechanism—cellular, molecular, and therapeutic aspects
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Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics
2022, Journal of Controlled ReleaseCitation Excerpt :α-lactalbumin (α-LAC) is an example of a protein with potential therapeutic effect in the treatment of GI-tract-related conditions, different neurological conditions as well as cancer, of which BNCs have been prepared [32–34,69]. Conjugation of α-LAC to oleic acid to form the complex named Human α-LAC Made Lethal to Tumor cells (HAMLET) potentiates its anti-cancer effect [70–72]. Using deionized water as solvent, ethanol as antisolvent and GTA as crosslinking agent post-desolvation, BNCs with a size of approximately 150 nm have been prepared.
Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy
2022, Materials Today BioCitation Excerpt :HAMLET or BAMLET (human/bovine α-lactalbumin made lethal against tumor cells), the widely known anticancer agent, are formed as the lipoprotein complex [25]. Since HAMLET was firstly identified from human milk in 1995, these anticancer agents have been extensively studied due to their noticeable ability to kill diverse cancers cells and negligible cytotoxicity to normal cells [26,27]. Notably, as α-lactalbumin is a major protein of natural dietary nutrient, HAMLET/BAMLET is regarded as extremely safe anticancer agent [28–31].
Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis
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