Short CummunicationCyclooxygenase and lipoxygenase arachidonic acid metabolism by monocytes from human immune deficiency virus-infected drug users
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Cited by (26)
PGJ<inf>2</inf> antagonizes NF-κB-induced HIV-1 LTR activation in colonic epithelial cells
2008, VirologyCitation Excerpt :During the time course of inflammation, the prostaglandins profile shifts from the predominantly pro-inflammatory PGE2 to the anti-inflammatory PGJ2, which is the end product metabolite of PGD2 (Gilroy et al., 1999; Ianaro et al., 2001; Kapoor et al., 2005a, 2005b). Pro-inflammatory molecules such as PGE2 are up-regulated during HIV-1 infection (Griffin et al., 1994; Ramis et al., 1991) leading to an imbalance in PGJ2 production. Given that the cyclopentone prostaglandin PGJ2 has potent anti-inflammatory properties, we examined whether the addition of PGJ2 could inhibit HIV-1 transcription in intestinal epithelial cells.
Peroxisome proliferator-activated receptor γ agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects
2002, Journal of Biological ChemistryIntracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: Role of prostaglandins
2002, Brain, Behavior, and ImmunityCitation Excerpt :The ex vivo technique reduces the contribution of the decapitation, because in this method the conversion of endogenous arachidonate to prostaglandins in brain tissues is measured after washing the tissues (Weidenfeld, Lysy, & Shohami, 1987). Although the finding that individuals infected with HIV have significantly higher levels of PGE2 than uninfected individuals is well established (Foley, Kazazi, Biti, Sorrell, & Cunningham, 1992; Griffin, Wesselingth, & McArthur, 1994; Ramis et al., 1991; Tarter et al., 1997), the role of gp120 in this elevation has been debated. In several studies, incubation of monocytes (Wahl et al., 1989), bronchial alveolar macrophages (Denis, 1994), or cultured astroglial cells (Mollace et al., 1994) with gp120 was found to induce the production of prostaglandins.
Prostaglandin E<inf>2</inf> inhibits replication of HIV-1 in macrophages through activation of protein kinase A
2002, Cellular ImmunologyCitation Excerpt :Experimental infection of PBM with HIV-1 results in an increase in the production of PGE2 relative to uninfected cultures [15]. In vitro production of thromboxane (TX) B2 by PBM of AIDS patients is also increased relative to normal controls [16,17]. The HIV-1 envelope glycoprotein gp120 also induces the production of PGE2 by normal PBM [15].