Reduced cerebrovascular blood flow velocities and vasoreactivity in open-angle glaucoma
Section snippets
Design
The study design was a nonrandomized observational cohort study.
Setting
The study was conducted at the University Hospital Ophthalmology Clinic at the Indiana University School of Medicine, Indianapolis.
Study population
Sixteen OAG patients and 15 normal subjects were enrolled in this study. The two groups were matched for age (mean age 60.8 ± 10.5 years for glaucoma patients, 53.7 ± 10.2 years for controls). Patients were described as suffering from OAG on the basis of characteristic optic nerve damage as well as visual field defect, regardless of the IOP. According to the
Results
Glaucoma patients and controls= were similar in systolic arterial BP and HR at baseline and during hyperoxia (Table 1). Diastolic blood pressure was significantly lower in controls than in glaucoma patients at baseline and during hyperoxia (Table 1). Intraocular pressure was statistically significantly higher in glaucoma patients both at baseline and during hyperoxia (Table 1). Intraocular pressure was unchanged from baseline during hyperoxia in both groups (Table 1). No change in blood
Discussion
The results of the current study suggest that total cerebral perfusion in OAG patients is reduced in comparison to age-matched controls. Our findings are in agreement with previous magnetic resonance imaging studies suggesting reduced total cerebral perfusion in normal tension glaucoma patients.10, 11 Normal tension glaucoma patients exhibit confluent deep white matter lesions known to be associated with decreased total cerebral perfusion.12, 13 Although mean velocity in the MCA is not a direct
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