Elsevier

Urology

Volume 80, Issue 2, August 2012, Pages 430-433
Urology

Pediatric Case Report
Bilateral Renal Cell Carcinoma in a Child

https://doi.org/10.1016/j.urology.2012.01.015Get rights and content

Renal cell carcinoma is a rare renal tumor in the pediatric population with an incidence of 0.1-0.3%. We report on the first case of bilateral renal clear cell carcinoma that was treated by partial nephrectomies. We performed a complete genetic evaluation to exclude a family inheritance and we looked at the deletions associated with the possible histologic subtypes of renal cell carcinoma. The patient had no evidence of recurrence after 80-month follow-up and her renal function remained normal.

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Case Report

In April 2004, an 8-year-old girl from Congola presented to the emergency department with a 5-day history of abdominal pain associated with nausea, vomiting, and diarrhea with rectorragia. She had no history of fever, weight loss, fatigue, urinary symptoms, or hematuria. She had no palpable abdominal mass and her blood pressure was normal.

During the initial evaluation by the pediatrician, hematologic workup and imaging were performed. Stool cultures were negative. The complete blood count

Comment

RCC accounts for 3% of all adult malignancies but is rare in the pediatric population, with an incidence of 0.1-0.3% of all neoplasms and representing 1.3-6.6% of all malignant renal tumors.1, 2, 3, 4 The incidence of RCC increases with age and the mean age at presentation is 8-9 years with no sex prevalence by most of series,1, 3, 5, 6 but a recent SEER database documented that 50% of pediatric RCCs were diagnosed after 15 years old.4

To our knowledge, this case represents the first bilateral

Conclusions

We reported the first case of bilateral RCC treated by bilateral partial nephrectomies in a child. After 80-month follow-up, the patient was recurrence-free and had normal renal function. This case raises the importance of considering nephron-sparing surgery in the pediatric population, particularly with bilateral tumors. In this population, we also have to suspect a genetic pattern with possible long-term recurrence.

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Financial Disclosure: The authors declare that they have no relevant financial interests.

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