Alternative TherapyA Dietary Intervention for Recurrent Prostate Cancer After Definitive Primary Treatment: Results of a Randomized Pilot Trial
Section snippets
Material and Methods
The participants were 36 men with biopsy-confirmed prostate cancer who had undergone primary treatment, had a subsequent increasing PSA level, and who had not received any other form of therapy within the previous 6 months. The participants were primarily non-Hispanic white men (91%). The average age was 69.1 years (SD 9.0), and the average body mass index was 30.1 (SD 4.4). Of the 36 men, 91% were married or partnered, and 40% reported a family history of prostate cancer; 20 had undergone
Flow of Participants
A total of 36 men in three cohorts agreed to participate. No significant differences at baseline were found between the two groups on the dietary or activity variables, age, or weight. Of the 17 randomized to the intervention condition, 10 fulfilled the study intervention requirements (attended 7 or more of the 11 classes and completed all assessments). Of the 19 men in the control group, 14 completed the study requirements. Of the 5 who withdrew from the study, 4 found the study requirements
Comment
The aim of this study was to determine whether men with prostate cancer recurrence could, after attending a series of dietary change classes and with the support of their partners, change to a study-compliant diet prepared at home, and whether this change would affect the men's QOL and a clinical marker for disease progression. The food consumption patterns at the 3-month follow-up visit indicated that the men were able to make significant changes in their diets in the desired direction,
Conclusions
Men with an increasing PSA level after primary treatment changed toward a diet recommended for prostate health that was sustained 3 months after intervention and was accompanied by increases in QOL. Although the log PSA slope for the groups was not significantly different, the PSA doubling time increased substantially in the intervention group compared with the controls. Future trials should examine the effect of a similar diet on clinical disease markers with a larger sample of men followed
Acknowledgment
To Adi Bemak for her support in instruction in the mindfulness component of the intervention.
References (20)
- et al.
Changes in diet, physical activity, and supplement use among adults diagnosed with cancer
J Am Diet Assoc
(2003) - et al.
Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growth
J Urol
(2001) - et al.
Intensive lifestyle changes may affect the progression of prostate cancer
J Urol
(2005) - et al.
Mindfulness-based approaches to eating disorders
- et al.
Role of diet in prostate cancer development and progression
J Clin Oncol
(2005) - et al.
The diet, prostate inflammation, and the development of prostate cancer
Cancer Metastasis Rev
(2002) - et al.
Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer
Prostate
(2006) - et al.
Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
Nutrition Cancer
(2004) - et al.
Association between current lifestyle behaviors and health-related quality of life in breast, colorectal and prostate cancer survivors
Psychol Health
(2004) - et al.
Mindfulness-based stress reduction and sense of coherence among women with fibromyalgia
J Clin Psychol Med Settings
(2002)
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2021, Journal of the Academy of Nutrition and DieteticsCitation Excerpt :Ingraham and colleagues25 examined fruit and vegetable intake with no between-group differences observed. Three studies assessed fiber intake.13,21,22 One study reported significantly higher intake in the intervention compared with the comparison group (P = 0.02),21 and the other 2 studies found no significant differences.13,22
This study was supported by a Department of Defense Medical Research Program New Investigator Award to J. Carmody.