Guest Editorial
Barometric whole body plethysmography and enhanced pause (PENH): How relevant are they?

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Cited by (14)

  • Repetitive measurements of enhanced pause (Penh)

    2015, Respiratory Physiology and Neurobiology
    Citation Excerpt :

    Zhang et al. (2009) compared the responsiveness of Penh and airway resistance measurements to methacholine in mice that were challenged with a single dose of ovalbumin on the same day, and the results revealed a significant increase in the Penh measurement group that was not observed in the airway resistance group. In addition to the evidence against Penh (Bates et al., 2004; Sly et al., 2005; Lundblad et al., 2007; Kirschvink, 2008; Adler et al., 2004; Pauluhn, 2004; Zhang et al., 2009), the results of the present study revealed that the Penh values at different time points are significantly different. In the present study, we not only measured the ratio Penh values (which were used in the study by Hamelmann et al. (1997)) but also simultaneously measured the absolute Penh values.

  • Comparison of direct and indirect bronchoprovocation testing using ventilator-acquired pulmonary mechanics in healthy cats and cats with experimental allergic asthma

    2013, Veterinary Journal
    Citation Excerpt :

    Measuring AHR has been used to diagnose disease, evaluate disease severity, monitor treatment efficacy, and adjust drug dosages in human asthmatics (Sont et al., 1999; O’Byrne, 2010; Brannan and Lougheed, 2012). In cats, airflow limitation has been estimated by tidal breathing flow-volume loops (McKiernan et al., 1993), forced expiratory flow-volume curves using thoracic compression (Bark et al., 2007), or barometric whole body plethysmography (BWBP; Hoffman et al., 1999; Kirschvink, 2008; Hirt et al., 2011). While minimally invasive, these techniques do not provide accurate direct measures of airway resistance, which is preferred for functional evaluation (Bates et al., 2004).

  • Advances in the understanding of pathogenesis, and diagnostics and therapeutics for feline allergic asthma

    2011, Veterinary Journal
    Citation Excerpt :

    Non-invasive pulmonary function testing, including tidal breathing flow-volume loops using a tight fitting face mask, forced expiratory flow-volume curves using a thoracic compression technique, or barometric whole body plethysmography (BWBP), have been used in cats to estimate airflow limitation (Bark et al., 2007; Hoffman et al., 1999; Kirschvink et al., 2007b; McKiernan et al., 1993). Recently there has been renewed interest in BWBP in cats, although results must be interpreted with caution since the index of airflow limitation measured by this technique called ‘enhanced pause’ (Penh) has been criticized for not reflecting pulmonary resistance as factors other than lower airway obstruction can impact Penh (Bates et al., 2004; Kirschvink, 2008). More direct and accurate means for estimating airway resistance require anesthesia and may be invasive (Dye et al., 1996; Norris Reinero et al., 2004; Padrid et al., 1995b).

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