Guest EditorialBarometric whole body plethysmography and enhanced pause (PENH): How relevant are they?
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Whole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Veterinary Journal
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Effects of cadmium chloride inhalation on airflow limitation to histamine, carbachol and adenosine 5′-monophosphate assessed by barometric whole body plethysmography in healthy dogs
Veterinary Journal
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Comparison of barometric whole body plethysmography and its derived parameter enhanced pause (PENH) with conventional respiratory mechanics in healthy Beagle dogs
The Veterinary Journal
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Comparison between pulmonary resistance and Penh in anaesthetised rats with tracheal diameter reduction and after carbachol inhalation
Journal of Pharmacological and Toxicological Methods
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Non-invasive assessment of growth, gender and time of day related changes of respiratory pattern in healthy cats by use of barometric whole body plethysmography
Veterinary Journal
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Inhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis
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Cited by (14)
Repetitive measurements of enhanced pause (Penh)
2015, Respiratory Physiology and NeurobiologyCitation Excerpt :Zhang et al. (2009) compared the responsiveness of Penh and airway resistance measurements to methacholine in mice that were challenged with a single dose of ovalbumin on the same day, and the results revealed a significant increase in the Penh measurement group that was not observed in the airway resistance group. In addition to the evidence against Penh (Bates et al., 2004; Sly et al., 2005; Lundblad et al., 2007; Kirschvink, 2008; Adler et al., 2004; Pauluhn, 2004; Zhang et al., 2009), the results of the present study revealed that the Penh values at different time points are significantly different. In the present study, we not only measured the ratio Penh values (which were used in the study by Hamelmann et al. (1997)) but also simultaneously measured the absolute Penh values.
Comparison of direct and indirect bronchoprovocation testing using ventilator-acquired pulmonary mechanics in healthy cats and cats with experimental allergic asthma
2013, Veterinary JournalCitation Excerpt :Measuring AHR has been used to diagnose disease, evaluate disease severity, monitor treatment efficacy, and adjust drug dosages in human asthmatics (Sont et al., 1999; O’Byrne, 2010; Brannan and Lougheed, 2012). In cats, airflow limitation has been estimated by tidal breathing flow-volume loops (McKiernan et al., 1993), forced expiratory flow-volume curves using thoracic compression (Bark et al., 2007), or barometric whole body plethysmography (BWBP; Hoffman et al., 1999; Kirschvink, 2008; Hirt et al., 2011). While minimally invasive, these techniques do not provide accurate direct measures of airway resistance, which is preferred for functional evaluation (Bates et al., 2004).
Effects of obesity on lung function and airway reactivity in healthy dogs
2012, Veterinary JournalAdvances in the understanding of pathogenesis, and diagnostics and therapeutics for feline allergic asthma
2011, Veterinary JournalCitation Excerpt :Non-invasive pulmonary function testing, including tidal breathing flow-volume loops using a tight fitting face mask, forced expiratory flow-volume curves using a thoracic compression technique, or barometric whole body plethysmography (BWBP), have been used in cats to estimate airflow limitation (Bark et al., 2007; Hoffman et al., 1999; Kirschvink et al., 2007b; McKiernan et al., 1993). Recently there has been renewed interest in BWBP in cats, although results must be interpreted with caution since the index of airflow limitation measured by this technique called ‘enhanced pause’ (Penh) has been criticized for not reflecting pulmonary resistance as factors other than lower airway obstruction can impact Penh (Bates et al., 2004; Kirschvink, 2008). More direct and accurate means for estimating airway resistance require anesthesia and may be invasive (Dye et al., 1996; Norris Reinero et al., 2004; Padrid et al., 1995b).
Endotracheal nebulization of N-acetylcysteine increases airway resistance in cats with experimental asthma
2011, Journal of Feline Medicine and Surgery