Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and maxillofacial radiologyThe efficacy of anticonvulsants on orofacial pain: a systematic review
Section snippets
Selection of studies
A computer-assisted search of the Cochrane, PubMed, and Ovid Medline database from 1966 through March 2010 was conducted, using the key words “orofacial pain,” “oral pain,” “facial pain,” “neuralgia,” “trigeminal neuralgia,” “tendomandibular dysfunction,” “burning mouth syndrome,” “odontalgia,” “(post) herpetic neuralgia,” “stomatodynia,” “atypical facial pain,” “cancer facial pain” in combination with “anticon*” and “(facial) pain.” The following limits were applied. Type of article:
Results
The search resulted in 16 RCTs with a variety of diagnoses, including neuropathic pain, such as refractory trigeminal neuralgia, neuropathic cancer pain, and postherpetic neuralgia, chronic masticatory myalgia, stomatodynia, traumatic nerve injury pain, and glossopharyngeal neuralgia.10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 In 8 studies the patient population consisted not only of patients with orofacial pain but also patients with other pain disorders.10, 11, 12, 13, 14,
Discussion
The present study was designed to provide information on the use of anticonvulsants in orofacial pain disorders.
Generally, the value of a review of the literature depends on the success on obtaining the results of all studies that have been conducted on the subject at issue. Reviews are subject to bias caused by the outcomes of published and unpublished studies differing (publication bias). Although much effort was put into obtaining all available studies, some important published and
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