Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and maxillofacial pathologyExpression of extracellular matrix metalloproteinase inducer in odontogenic cysts
Section snippets
Tissue specimens
The original hematoxylin and eosin (H&E)–stained sections and formalin-fixed paraffin-embedded specimen blocks of all OKCs, DCs, and PAs diagnosed between January 2004 and October 2005 were retrieved from the Department of Histopathology, Amiri Hospital, Kuwait City, Kuwait. The H&E sections were reviewed to confirm the diagnosis. Cysts not satisfying the histologic criteria outlined by the World Health Organization classification,18 intensely inflamed OKCs and DCs, orthokeratinized OKCs, OKCs
Results
Of the 48 cysts assessed, 29 (60.4%) were found in males and 19 (39.6%) were found in females. Thirteen cysts (27.1%) were seen in the maxilla and 35 (72.9%) in the mandible. The median patient age was 27 years (range, 6-62 years; Table I).
EMMPRIN was detected in all of the odontogenic cysts and DFs. EMMPRIN staining was detected in the cell membrane of both the basal and the suprabasal odontogenic epithelial cells (Fig. 1). EMMPRIN showed continuous and uniform expression in both the basal and
Discussion
The MMPs are a family of enzymes that have the ability to degrade different components of the extracellular matrix.1 More than 20 different MMPs have been identified.2 The MMPs are classified based on structure and substrate specificity into subgroups of collagenases, gelatinases, stromelysins, matrilysins, and membrane-type MMPs (MT-MMPs).2 The MMPs play an important role in several physiologic and pathologic processes, including embryonic development, morphogenesis, reproduction, and tissue
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