Donor managementEstablishing a Brain-Death Donor Model in Pigs
Section snippets
Materials and Methods
All animal experiments were performed after approval by the local ethical committee according to Austrian animal law.
Results
The inflated balloon catheter caused brain damage and consecutively BD in all 15 animals (Fig 2) at 60 minutes after BD induction, neurological and EEG examinations confirmed BD (Fig 3A, 3B). Intracranial pressure increased continuously, remaining stable after the occurrence of BD. All 15 animals showed typical signs of BD, such as diabetes insipidus, hypertensive and hypotensive periods, and tachycardia. All symptoms were treated with standard medication. Baseline levels and values during 24
Discussion
Several BD models have already been described mostly using animal rats, dogs, and pigs.23, 31, 32 These studies investigated hemodynamic, metabolic, and endocrine changes during and after BD as well as the effects of hormone replacement therapy.9, 12, 16, 19, 21, 23, 33, 34 However, BD and donor care never exceeded 12 hours.
In many animal studies of BD, domestic pigs have been used because of their availability and resemblance to the human cardiovascular system. Two methods have been used to
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M.S. and P.S. contributed equally to this work.