Case reportKidneyA Case of Living-Donor Renal Transplantation for Chronic Renal Failure Caused by Secondary Amyloidosis
Section snippets
Case Report
The patient was a 50-year-old woman who at age 38 years was diagnosed with acute renal failure. Renal biopsy revealed deposition of AA amyloid and the cause of renal failure was secondary amyloidosis. Consistent with secondary amyloidosis, we suspected aortitis syndrome from imaging findings, eg, stenosis of the subclavian artery, but could not confirm the diagnosis.
Although she began steroid therapy, the renal function worsened progressively, and she started hemodialysis at the age of 40
Discussion
AA-type amyloidosis mostly develops due to a chronic inflammatory disease, for example, tuberculosis, rheumatoid arthritis, or an autoimmune disease. Patients with AA-type amyloidosis show amyloid protein deposits in glomeruli, vessels, renal tubules, and interstitial tissues. In many cases, the amyloid deposition decreases renal function, resulting in renal failure. Amyloid protein can also deposit in other vital organs (eg, heart and liver), leading to cardiac or liver dysfunction. The
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