Elsevier

Tetrahedron Letters

Volume 58, Issue 29, 19 July 2017, Pages 2846-2849
Tetrahedron Letters

Toward a highly sensitive and selective indole-rhodamine-based light-up probe for Hg2+ and its application in living cells

https://doi.org/10.1016/j.tetlet.2017.06.024Get rights and content

Highlights

  • A novel light-up fluorescent probe (L1) based on indole derivative and Rhodamine fluorophore for Hg2+ species was developed.

  • The probe L1 can show a linear response to Hg2+ with high sensitivity and selectivity, and its detection limit was 5.0 × 10−8 M.

  • Futhermore, probe L1 can be successfully applied to monitor Hg2+ species in living MCF-7 cells by fluorescence imaging.

Abstract

We herein designed and synthesized a light-up fluorescent probe L1 for Hg2+ species, which is based on indole derivative and Rhodamine fluorophore. The new probe can show a linear response to Hg2+ with high sensitivity and selectivity. As the Hg2+ concentration changed from 0 to 450 μM, the fluorescence intensity of L1 at 575 nm changed from 50 to 6181 (∼120-fold). The detection limit of the probe was 5.0 × 10−8 M. Besides, we have successfully applied L1 to monitor Hg2+ species in living MCF-7 cells by way of fluorescence imaging.

Section snippets

Acknowledgments

We thank the financial support from the National Natural Science Foundation of China (51578224) and the Natural Science Foundation of Hunan Province (2015JJ4018).

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