Elsevier

Tetrahedron Letters

Volume 53, Issue 14, 4 April 2012, Pages 1738-1741
Tetrahedron Letters

Iodine-catalyzed three-component one-pot synthesis of naphthopyranopyrimidines under solvent-free conditions

https://doi.org/10.1016/j.tetlet.2012.01.096Get rights and content

Abstract

Iodine is found to be a highly efficient catalyst for the three-component coupling (3CC) of aldehydes, β-naphthol, and 1,3-dimethylbarbituric acid under solvent-free conditions to afford the corresponding 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′5,6]pyrano[2,3-d]pyrimidine-9,11-diones in good yields with high selectivity. The use of readily available iodine makes this method very simple, convenient, and cost-effective.

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Acknowledgements

K.P., S.S. and G.N. are thankful to the Council of Scientific and Industrial Research, New Delhi, India, for the award of fellowships. P.L.R. is thankful to UGC, for the award of a fellowship.

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