First total synthesis of (±)-epocarbazolin A and epocarbazolin B, and asymmetric synthesis of (−)-epocarbazolin A via Shi epoxidation
Graphical abstract
Epoxidation of the trisilyl-protected carbazomadurins A and B with dimethyldioxirane followed by desilylation provides racemic epocarbazolin A and epocarbazolin B. The Shi epoxidation has been applied to an asymmetric synthesis of (−)-epocarbazolin A.
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Acknowledgments
We thank the Fonds der Chemischen Industrie for financial support of our project.
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