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doi:10.1016/j.tetlet.2005.07.018 
Copyright © 2005 Elsevier Ltd All rights reserved.
Microwave-assisted cyclocondensation of hydrazine derivatives with alkyl dihalides or ditosylates in aqueous media: syntheses of pyrazole, pyrazolidine and phthalazine derivatives
Received 17 May 2005;
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Abstract
Direct syntheses of 4,5-dihydro-pyrazole, pyrazolidine, and 1,2-dihydro-phthalazine derivatives via double-alkylation of hydrazines by alkyl dihalides or ditosylates were accomplished in aqueous media under microwave irradiation conditions; the environmentally friendlier chemical transformation occurred in a single step and eliminated the use of expensive metal catalysts in building two C–N bonds.
Graphical abstract
Direct microwave-assisted syntheses of 4,5-dihydro-pyrazole, pyrazolidine and 1,2-dihydro-phthalazine derivatives from hydrazines and alkyl dihalides or ditosylates were achieved in aqueous alkaline media.
Keywords: Cyclocondensation; Microwave irradiation; Heterocycles; 4,5-Dihydro-pyrazole; 1,2-Dihydro-phthalazine
