Trends in Endocrinology & Metabolism
Research FocusLong-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
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Acknowledgements
Studies in our laboratory related to this topic are supported by the National Institute on Aging and by the Ellison Medical Foundation.
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Cited by (83)
Serum klotho protein levels and their correlations with the progression of type 2 diabetes mellitus
2017, Journal of Diabetes and its ComplicationsTetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1
2015, Neurobiology of AgingCitation Excerpt :Reduced level of Klotho has also been observed in the brains of aged mammals (Duce et al., 2008). Klotho ablates the effect of the insulin/IGF-1 signaling pathway's signals with aging process and can be mutually regulatory (Bartke, 2006). Consistent with the theory, TSG delays aging by increasing the levels of klotho in aged mice (Xu et al., 2009).
Fibroblast growth factor 23 and Klotho serum levels in healthy children
2014, BoneCitation Excerpt :Thus, the higher Klotho levels in girls and pubertal children we found, in the presence also of higher IGF-I levels in the same groups, could reflect a counterregulatory action on the IGF-I sparing effect on phosphate in order to maintain an appropriate phosphate homeostasis. In addition, we cannot exclude that Klotho increases secondary to increased IGF-I levels in order to inhibit the augmented IGF-I signaling according to in vitro studies [50–54]. To our knowledge, this is so far the largest study in healthy children where FGF23 and Klotho were measured simultaneously.
The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review
2023, International Journal of Molecular SciencesRenal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals
2022, Frontiers in Cardiovascular Medicine