American Association of Endocrine SurgeonsE-selectin expression and BRAF status in papillary thyroid carcinomas: Correlation with clinicopathologic features
Section snippets
Methods
Formalin-fixed and paraffin-embedded (FFPE) thyroid specimens from 88 patients (20 male, 68 female) with a conventional variant of PTC who underwent operation at the Department of Surgical Pathology from January 2006 to December 2012 were retrospectively reviewed. Patients were a mean age of 41.0 ± 14 years (range, 12–78 years). The mean tumor size was 18.6 ± 1.4 mm (range, 15.0–20.0 mm). This study was approved by the Institutional Review Board, and informed consent was obtained from all
Results
We analyzed 88 tumors histologically diagnosed as conventional variant of PTC and whose size was <20 mm. According to the degree of neoplastic infiltration, 41 of the 88 tumors were totally encapsulated, and 47 had extrathyroidal invasion. Tumor multifocality was observed in 36 patients (41%). Lymph node metastases were identified in 21 patients (24%), 7 in whom they were only in the central compartment, and 14 in whom they also were in lateral compartment. Lymphocytic thyroiditis was observed
Discussion
The histologic demonstration of extrathyroidal extension has been described as having the “most significant bearing on prognosis” in patients with well-differentiated PTC.20 Moreover, oncologic outcome of patients with PTC correlates with the degree of extent of extrathyroidal invasion.3, 4 On one hand, outcome is worse in patients with gross extrathyroidal disease extension than in those with microscopic local invasion apparent on the histopathologic assessment.4 On the other hand, the
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