Original CommunicationPreoperative total cholesterol predicts postoperative outcomes after partial hepatectomy in patients with chronic hepatitis B- or C-related hepatocellular carcinoma
Section snippets
Study population
From January 2003 to December 2009, 1,015 consecutive liver resections were carried out for HCC at the Hepatic Surgery Center of Tongji Hospital. The demographic and perioperative data and the types of operations were collected prospectively and entered into a computer database. Nineteen patients with obstructive jaundice were excluded from the study, because obstructive jaundice caused hypercholesterolemia, the TC level could not reflect liver damage. This resulted in a total of 996 patients
Demographics
A total of 996 patients were included in the study (Table I). There were 873 men and 123 women, and the average age was 48 years (range, 12–85). Nine hundred seventy-nine patients (98%) had HBV infection and 21 (2%) had HCV infection; 4 among them (0.4%) had combined HCV and HBV infection. Eight hundred and forty-nine patients had liver cirrhosis (85%); 216 of them had serious liver cirrhosis. The mean preoperative TC level was 3.52 ± 1.00 mmol/L, the mean ICGR-15 rate was 6.6 ± 4.1%, and the
Discussion
Compared with Western series,1, 25 there are more patients with HBV- or HCV-related cirrhosis (85.2%) in this study. Cirrhotic liver tolerates tissue loss poorly, and has impaired function and a decreased ability to regenerate.26 To ensure favorable perioperative outcomes in patients with chronic liver diseases undergoing partial hepatectomy, careful patient selection is important.9, 27, 28 Methods have been developed to assess preoperative hepatic functional reserve, such as the ICG retention
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Preoperative indocyanine green (ICG) clearance test: Can we really trust it to predict post hepatectomy liver failure? A systematic review of the literature and meta-analysis of diagnostic test accuracy
2022, Photodiagnosis and Photodynamic TherapyCitation Excerpt :PPV ranged from 17.9% [27] to 31% [16] and NPV ranged from 84% [15] to 95% [32]. Ten studies reported mean/median ICGR15 values in patients suffering PHLF [15,18,20,22–28]. The weighted mean ICGR15 under random effects model was 11 (95%CI: 8.3-13.7) (Fig. 3A).
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2022, European Journal of RadiologyCitation Excerpt :We found no statistically significant difference between the quantitative parameters and combined them with sFLR in predicting PHLF, symptomatic PHLF, and OS. This finding may be because patients planned to have smaller remnant liver after hepatectomy were more carefully selected and had better liver function than those planned to have larger remnant liver [37,38]. This study has some limitations.
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2020, International Journal of SurgeryCholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis
2019, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Previous clinical studies have demonstrated that the serum cholesterol level is inversely correlated with HCC incidence and positively associated with the prognosis [6,18], but the causality of the correlation between cholesterol and HCC requires consideration. Initially, considering the liver is the major organ synthesizing cholesterol, researchers argued that the low level of cholesterol in HCC patients may be the result of chronic liver disease and malnutrition [7,19]. However, recent studies revealed an inverse correlation between cholesterol and HCC metastasis in patients with comparable liver function [11].
Supported by grants from the state key project on infectious diseases of China (Grant No. 2008ZX10002-025).