Cell Stem Cell
Volume 24, Issue 3, 7 March 2019, Pages 351-352
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FOXO3, a Molecular Search for the Fountain of Youth

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FOXO3 has been consistently associated with longevity and with a reduction in the prevalence of cardiovascular disease. In this issue, Yan et al. (2019) report that FOXO3-activated vascular cells derived from human embryonic stem cells (ESCs) promote multiple vascular functions and reverse cellular aging through the transcriptional repression of CSRP1.

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