EditorialThe roles of retinoic acid in lymphocyte differentiation
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Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity
2014, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Only within the past decade have the initial molecular details whereby vitamin A contributes to immunity been delineated [1]. Although multiple isomers exist, all-trans-retinoic acid (atRA) is the most abundant within human cells and is required for a spectrum of immune-related functions including cellular proliferation and differentiation, antibody production, and cytokine secretion [5–9]. Classically, atRA and other vitamin A derivatives exert their influence by activating two distinct family of nuclear steroid receptors known as the retinoic acid receptor (RAR) and retinoid X receptor (RXR) family [10,11].
9-cis-Retinoic acid promotes cell adhesion through integrin dependent and independent mechanisms across immune lineages
2013, Journal of Nutritional BiochemistryCitation Excerpt :However, we have recently shown that at-RA can also prompt integrin-independent cell adhesion in a particular human B-cell line [29]. The contribution and influence of at-RA to a variety of immune processes including leukocyte differentiation, proliferation, antibody secretion and adhesion is addressed in the literature, but there is a paucity of information evaluating if 9-cis-RAor other isomers contribute to immune processes [4,5,24,29–31]. Given the promiscuous nature of RXRs and the ability of 9-cis-RA to activate both RARs and RXRs, 9-cis-RA may serve as an immunomodulating compound that influences a spectrum of immune events including cell adhesion.
Nutrition and Micronutrients in Tropical Infectious Diseases
2011, Tropical Infectious Diseases: Principles, Pathogens and PracticeNutrition and Micronutrients in Tropical Infectious Diseases
2011, Tropical Infectious DiseasesAll-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells
2011, Cellular ImmunologyCitation Excerpt :The result was confirmed by confocal microscopy, with a similar distribution of staining but less bright staining in cells that were treated with PMA plus either PD98059 or SB203580 (Fig. 4D). Recently, there has been significant progress in elucidating the roles of RA in the regulation of immune cell activities [21–23,45–48]. In the present study, we investigated the role of RA in the expression regulation of CD300B, a novel member of the leukocytes surface molecule family, and we also investigated the putative signaling pathways involved in the regulation of CD300B expression.
Retinoic acid inhibits dendritic cell differentiation driven by interleukin-4
2009, Cellular ImmunologyCitation Excerpt :Moreover it was suggested that retinoids may affect Th1 dominant autoimmune diseases [4]. Some studies showed retinoic acid involvement in neutrophils differentiation and apoptosis [5], others were focused on lymphocytes [6,7]. It is believed that effects of retinoids on immune responses might also be mediated by DCs.