Fig. 1. Locations of kainate receptors in hippocampal CA3 pyramidal neurons. For this and Fig. 2, subunit information is provided where there is positive evidence for the presence of a particular subunit. See text for references and details.

Fig. 2. Locations of kainate receptors in hippocampal GABAergic CA1 interneurons. See text for references and details.

Fig. 3. GluR5 and GluR6 C-terminal splice variants. (A) Diagram depicting the GluR5 and GluR6 C-terminal splice variants from the fourth transmembrane domain (TM4) through the entire C-terminus. Conserved domains are depicted with identical patterns. (B) Alignment of the amino acid sequences of the GluR5 and GluR6 splice variants through the pertinent C-terminal regions. Accession numbers for the rat GluR5 splice variants depicted are as follows: GluR5-a (Z11712), GluR5-b (Z11713), and GluR5-c (Z11714). Accession numbers for the human GluR6 splice variants depicted are as follows: GluR6-a (NM021956) and GluR6-b (AJ301610).

Fig. 4. Tac kainate receptor chimeras used to identify C-terminal motifs that regulate trafficking through the secretory pathway. A schematic depicts the structure of Tac kainate receptor chimeras described in several recent publications. The subcellular localization of each of these constructs is listed. References for each of these findings are included.

Fig. 5. Schematic of kainate receptor C-termini depicting the location of defined motifs that regulate trafficking through the secretory pathway. The positively charged motifs within GluR5 and KA2 regulate ER retention, whereas the positively charged motif in GluR6 regulates egress from the ER.

mRNA expression levels for kainate receptor subunits in neurons in the hippocampal formation

For references, see accompanying text. Key: +++, high; ++, moderate; +, low; −, not detected.