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Peptides
Volume 26, Issue 4, April 2005, Pages 701-705
 
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doi:10.1016/j.peptides.2004.11.010    
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Copyright © 2004 Elsevier Inc. All rights reserved.

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Deficit in beta-endorphin peptide and tendency to alcohol abuse

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Jadwiga Zalewska-KaszubskaCorresponding Author Contact Information, E-mail The Corresponding Author and Elżbieta Czarnecka

Department of Pharmacodynamics, Medical University of Lodz, Muszynskiego 1, PL 90-151 Lodz, Poland


Received 30 August 2004; 
revised 9 November 2004; 
accepted 10 November 2004. 
Available online 18 December 2004.

Abstract

Human and animal studies suggest that there is a correlation between endogenous opioid peptides, especially beta-endorphin, and alcohol abuse. It has been proven that the consumption of alcohol activates the endogenous opioid system. Consumption of alcohol results in an increase in beta-endorphin level in those regions of the human brain, which are associated with a reward system. However, it has also been observed that habitual alcohol consumption leads to a beta-endorphin deficiency. It is a well-documented phenomenon that people with a genetic deficit of beta-endorphin peptide are particularly susceptible to alcoholism. The plasma level of beta-endorphin in subjects genetically at high risk of excessive alcohol consumption shows lower basal activity of this peptide. Its release increases significantly after alcohol consumption. Clinical and laboratory studies confirm that certain genetically determined factors might increase the individual's vulnerability to alcohol abuse.

Keywords: Alcohol abuse; Beta-endorphin; Genetic factors

Article Outline

1. Introduction
2. Laboratory studies
3. Clinical studies
4. Genetic studies
5. Summary
References

Corresponding Author Contact InformationCorresponding author. Tel.: +48 42 6779299; fax: +48 42 788398.

Peptides
Volume 26, Issue 4, April 2005, Pages 701-705
 
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