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Section snippets
IOL Dislocation, Pseudoexfoliation Syndrome, and Glaucoma Severity
In an analysis of spontaneous intraocular lens (IOL) dislocation in patients with pseudoexfoliation syndrome (PXF), Leung et al (p. 480) assessed the differences in the presence and severity of glaucoma between fellow eyes in affected patients. They found that IOL dislocation was more likely to occur in eyes with glaucoma, particularly in those eyes with severe disease. For this retrospective matched case-control study, the researchers identified 71 patients who had undergone uneventful
Anti-VEGF Treatment for AMD and Meaningful Visual Function
In a secondary analysis from the VIEW 1 and 2 studies, Yuzawa et al (p. 571) evaluated the effect of intravitreal aflibercept and ranibizumab on visual function in patients with age-related macular degeneration (AMD). They found that baseline scores from the National Eye Institute's Visual Function Questionnaire (NEI VFQ-25) were similar for both treatments in both studies, with clinically meaningful improvement noted in 6 of 12 subscales over a 52-week period. The VIEW studies were
Overnight Orthokeratology for Progressive Myopia in Children
Swarbrick et al (p. 620) investigated the effect of orthokeratology (OK) contact lens wear on axial length in East Asian children with progressive myopia. They found that overnight OK lens wear is more effective at inhibiting axial eye growth and myopia progression than daytime wear of a conventional rigid gas-permeable (GP) lens. For this prospective study, which used a contralateral eye crossover design, 26 children wore an OK lens in one eye overnight and GP lenses in both eyes during the
RNFL Measurements in Uveitis
Moore et al (p. 511) evaluated retinal nerve fiber layer (RNFL) measurements in uveitic eyes with and without glaucoma and compared the results to published age-adjusted normative data. They found that uveitis is a major confounding factor in assessing the thickness of the RNFL. For this comparative retrospective study, the researchers identified 76 uveitic eyes without glaucoma and 135 uveitic eyes with glaucoma. Global and sectoral RNFL measurements were taken with spectral-domain optical
Early Results with AKB-9778 for DME
Campochiaro et al (p. 545) tested the safety and activity of AKB-9778, a new compound, in patients with diabetic macular edema (DME). They found that the drug—which activates Tie2 and suppresses vascular leakage and ocular neovascularization—was well tolerated and produced improvements in best-corrected visual acuity (BCVA) from baseline in those who received ≥15 mg twice a day. In addition, modest and transient reductions in blood pressure were noted with higher doses (≥25 mg). For this