Original articlePredicted Long-term Outcome of Corneal Transplantation
Section snippets
Study Design
One thousand three hundred consecutive penetrating keratoplasties and deep anterior lamellar keratoplasties carried out in 1144 patients between December 1992 and September 2006 were studied. Data were recorded prospectively and then were analyzed retrospectively. In the 156 patients (12%) who received 2 grafts in the same or contralateral eye during the study period, only the first graft was included in the study, yielding a total of 1144 procedures in 1144 patients. Between 1992 and 2001, all
Overall Results
The average follow-up time (from surgery to failure for unsuccessful grafts or from surgery to the date of last visit for successful grafts) was 40.5±32.1 months (Table 2). The percentage of patients lost to follow-up or deceased was 7% (81/1144) at 12 months after surgery, 29% (318/1090) at 36 months, 45% (409/910) at 60 months, and 60% (289/484) at 120 months. The observed 5- and 10-year graft survival estimates were, respectively, 74.3% and 64.4% (Fig 1). The average ECD (and endothelial
Discussion
In the present study, the overall observed graft survival after corneal transplantation was 74% at 5 years and 64% at 10 years, and the predicted graft survival was 27% at 20 years and 2% at 30 years. Both observed graft survival and predicted graft survival were higher in patients who underwent deep anterior lamellar keratoplasty than in patients who underwent penetrating keratoplasty and had normal recipient endothelium and were higher in patients who underwent penetrating keratoplasty and
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Available online: October 7, 2009.
Manuscript no. 2009-115.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by UPMC University of Paris 06, Paris, France.