Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Oral medicineEfficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial
Section snippets
Participants
Sixty-one patients with erosive OLP determined clinically and pathologically were enrolled at the Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, from April 1, 2011, to May 31, 2012. Of these 61 patients, 21 were men and 40 were women, aged 18 to 60 years. Participants were randomly divided into 2 groups: 30 in the experimental group and 31 in the control group.
The inclusion criteria were as follows: age, 18 to 60 years; having a single erosive lesion;
Results
A total of 100 patients with erosive OLP were assessed for eligibility to participate in the study at the Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, from April 1, 2011, to May 31, 2012. Of these, 34 did not meet the inclusion criteria; 25 had bilateral or multiple erosions, and 5 others refused to participate in the study. A total of 61 participants, 30 in the experimental group and 31 in the control group, were enrolled in the study. Two patients were
Efficacy of intralesional betamethasone in the treatment of erosive OLP
This study was a randomized, positive-controlled clinical trial that compared the efficacy of intralesional betamethasone and triamcinolone acetonide in the treatment of erosive OLP. In our research, we designed a blind evaluation, which in this study involved the injection by one researcher and the recording of the observed indicators, such as erosive area and pain level, by different researchers who were blinded to the medications for the whole treatment duration. In this way, we tried to
References (41)
- et al.
Oral mucosal disease: lichen planus
Br J Oral Maxillofac Surg
(2008) - et al.
Oral lichen planus and malignant transformation: a longitudinal cohort study
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2011) - et al.
A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2010) Treatment of erosive lichen planus of the oral mucosa with depot steroids
Lancet
(1977)- et al.
Betamethasone oral mini-pulse therapy compared with topical triamcinolone acetonide (0.1%) paste in oral lichen planus: a randomized comparative study
J Am Acad Dermatol
(2008) - et al.
Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus
J Am Acad Dermatol
(2002) - et al.
Validity, reliability, and clinical importance of change in a 0-10 numeric rating scale measure of spasticity: a post hoc analysis of a randomized, double-blind, placebo-controlled trial
Clin Ther
(2008) - et al.
Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study
Oral Surg Oral Med Oral Pathol Oral Radiol
(2012) - et al.
Pharmacology of glucocorticoids: beyond receptors
Eur J Pharmacol
(2008) - et al.
Modulation of glucocorticoid action and the treatment of type-2 diabetes
Best Pract Res Clin Endocrinol Metab
(2007)
Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states
Neurosci Biobehav Rev
Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes
Prog Brain Res
Oral lichen planus: update on etiopathogenesis, diagnosis and treatment
Immunopharmacol Immunotoxicol
A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain
J Oral Pathol Med
Course of oral lichen planus: a retrospective study of 808 northern Italian patients
Oral Dis
A retrospective clinicopathological study on oral lichen planus and malignant transformation: analysis of 518 cases
Med Oral Patol Oral Cir Bucal
Oral lichen planus: an update on pathogenesis and treatment
J Oral Maxillofac Pathol
Systematic review of current systemic treatment options for erosive lichen planus
Expert Rev Dermatol
Steroids in the treatment of lichen planus: a review
Oral Sci
Effective treatment of erosive lichen planus with thalidomide and topical tacrolimus
Int J Dermatol
Cited by (35)
Does Betamethasone Injection Into the Pterygomandibular Space Affect the Postoperative Outcomes of Impacted Lower Third Molar Surgery?
2023, Journal of Oral and Maxillofacial SurgeryComposite dissolvable microneedle patch for therapy of oral mucosal diseases
2022, Biomaterials AdvancesCitation Excerpt :The MNs are prepared by a two-step casting process and the drug is concentrated in the tip parts of the needles to achieve efficient and precise drug release. Betamethasone sodium phosphate (BSP) is a long-acting GCs, which has been applied in the clinical treatment of many oral mucosal inflammatory diseases with significant efficacy. [36–38] Thus, BSP is selected as the model drug in this study.
Hydroxychloroquine and the treatment of Sjogren syndrome, chronic ulcerative stomatitis, and oral lichen planus in the age of COVID-19
2021, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :Injectable steroid therapeutic drugs include triamcinolone and betamethasone. Other alternative therapeutics include topical retinoid therapy and low-level laser therapy.19-27 The major issue with respect to dental patients taking HCQ is drug-to-drug interactions with concerns regarding arrhythmogenic potential, specifically the TdP arrhythmia, which is potentially lethal.
Comparative evaluation of effectiveness of autologous platelet rich plasma and intralesional corticosteroids in the management of erosive oral Lichen planus- a clinical study
2020, Journal of Oral Biology and Craniofacial ResearchCitation Excerpt :Extensive past research has proven effectiveness of intralesional steroids in treatment of Oral Lichen planus such as studies conducted by Liu, Chuanxia et al. and Lee, Young Chan et al. Xia, and Juan et al. which observed similar positive results as the present study.5,14,15 However, on comparing both the groups, no statistically significant differences were observed between the two groups.
Intralesional triamcinolone acetonide therapy for inflammatory oral ulcers
2019, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyPremalignant and malignant oral mucosal lesions: Clinical and pathological findings
2019, Journal of the American Academy of DermatologyCitation Excerpt :Initial treatment of symptomatic OLP is usually done with topical steroids. Intralesional corticosteroids have been used in the treatment of erosive OLP.41 Systematic steroids are used in more severe or refractory cases.33