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Neuropsychologia
Volume 45, Issue 12, 2007, Pages 2827-2838
 
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doi:10.1016/j.neuropsychologia.2007.05.005    How to Cite or Link Using DOI (Opens New Window)
Copyright © 2007 Elsevier Ltd All rights reserved.

Within-person trial-to-trial variability precedes and predicts cognitive decline in old and very old age: Longitudinal data from the Berlin Aging Study

Martin LövdénCorresponding Author Contact Information, a, E-mail The Corresponding Author, Shu-Chen Lia, E-mail The Corresponding Author, Yee Lee Shinga, E-mail The Corresponding Author and Ulman Lindenbergera, E-mail The Corresponding Author

aCenter for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallée 94, D-14195 Berlin, Germany

Received 17 October 2006; 
revised 6 April 2007; 
accepted 7 May 2007. 
Available online 17 May 2007.

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Abstract

Neurocomputational modeling and empirical evidence suggest that losses in neuronal signaling fidelity cause senescent changes in behavior. We applied structural equation modeling to five-occasion 13-year longitudinal data from the Berlin Aging Study (n = 447; age range at t1 = 70–102 years) to test whether trial-to-trial reaction time variability in perceptual speed (identical pictures) antecedes and signals longitudinal decline in levels of performance on perceptual speed (digit letter and identical pictures) and ideational fluency (category fluency). Higher trial-to-trial variability preceded and predicted greater cognitive decline in perceptual speed and ideational fluency. We conclude that trial-to-trial variability signals impending decline in cognitive performance, and that theories of neurocognitive aging need to postulate developmental cascades between senescent changes in variability and central tendency.

Keywords: Within-person variability; Inconsistency; Neuronal noise; Longitudinal change; Neurocognitive aging; Cognitive control

Article Outline

1. Method
1.1. Participants
1.2. Measures
1.2.1. Category fluency
1.2.2. Digit letter
1.2.3. Trial-to-trial variability (identical pictures)
1.3. Statistical procedures
2. Results
2.1. Are changes in trial-to-trial variability associated with changes in cognitive performance levels?
2.2. Is high trial-to-trial variability preceding and predicting decline in cognitive performance levels?
3. Discussion
Acknowledgements
References




Neuropsychologia
Volume 45, Issue 12, 2007, Pages 2827-2838
 
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