Electrical stimulation of locus coeruleus strengthens the surround inhibition in layer V barrel cortex in rat
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Acknowledgements
This experiment were supported by Kerman Neuroscience Research Center, Kerman University of Medical Sciences and Kerman Management and Planning Organization. We thank Dr. Mohsen Reza Haidary for assistance with English editing of the manuscript.
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The locus coeruleus-norepinephrine system and sensory signal processing: A historical review and current perspectives
2019, Brain ResearchCitation Excerpt :Further studies investigating the effects of LC activation on somatosensory signal processing confirm and extend many of the above findings. Motaghi et al. (2006) have shown that electrical stimulation of LC increases the magnitude of layer V barrel field cortical neuron excitatory responses to individual whisker deflection and strengthens surround inhibition, a powerful combination of effects that can focus excitatory synaptic drive to cortical neurons and sharpen their receptive field borders. Fazlali and colleagues (2016) have provided evidence linking LC spontaneous firing rate to cortical activation, i.e. high frequency, low amplitude waveforms within EEG recordings that are associated with alert brain states and higher order cognitive processing.
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