Expression of estrogen receptor-β in the postischemic monkey hippocampus
Section snippets
Acknowledgments
This study was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan to T.Y., and from Japan Society for the Promotion of Science to K.K. We thank Dr. Yoshinori Imai (National Institute of Neuroscience, Tokyo, Japan) for supplying Iba1 antibody.
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Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :ERα and ERβ mRNA have been detected in rat primary microglia [6], but there are no reports on ER protein expression in primary microglia. The expression of ERβ was upregulated in monkey microglia during ischemia [27], suggesting that the stress response regulated ER expression. Sierra et al. reported that mouse microglia isolated based on c-fms promoter activity expressed ERα, but not ERβ [28].
Estrogen receptors and ischemic neuroprotection: Who, what, where, and when?
2013, Brain ResearchCitation Excerpt :The only published report of ERβ colocalization comes from monkeys in which transient forebrain ischemia led to a decrease in ERβ staining in CA1 pyramidal neurons of the hippocampus 4 days after injury Takahashi, [2004 #3919]. However, ERβ expression increased in the radiate and molecular layer and was localized in astrocytes and microglia (Takahashi et al., 2004). Similarly, there is only one published report on the localization of GPER in stroke.
Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats
2012, Brain ResearchCitation Excerpt :Both ERs are expressed in the rodent hippocampus but ER-β is more prevalent regulating hippocampal synaptic plasticity (Mitra et al., 2003) and improving neuronal survival. Increased ER-β immunoreactivity in the post-ischemic monkey hippocampus has also been found (Takahashi et al., 2004). There are several lines of evidence that ER-β is involved in neuroprotection (Sawada et al., 1998).
Actions of estrogens on glial cells: Implications for neuroprotection
2010, Biochimica et Biophysica Acta - General SubjectsNeuroprotective effects of genistein in mongolian gerbils: Estrogen receptor-β involvement
2010, Journal of Pharmacological SciencesERβ in CNS: New roles in development and function
2010, Progress in Brain ResearchCitation Excerpt :Western blotting and immunohistochemistry of the adult hippocampus revealed lower protein levels of ERα than ERβ (Gonzalea et al., 2007). In the macaque monkey brain, ERβ is widely expressed in the adult hippocampus, whereas ERα immunoreactivity is either absent or very rare (Takahashi et al., 2004). Interestingly, ultrastructural analysis of the brains of rats at diestrus revealed that the cellular and subcellular localization of ERβ-IR was generally similar to that of ERα, except that ERβ was more extensively found at extranuclear sites.