Regular Article
Alteration of microvascular permeability in acute kidney injury

https://doi.org/10.1016/j.mvr.2008.09.004Get rights and content

Abstract

Functional and structural abnormalities in the renal microvasculature are important processes contributing to the pathophysiology of ischemic acute kidney injury (AKI). Renewed interest in the complex interplay between tubular injury, inflammation and microvascular alterations has emerged in order to gain a better understanding of acute kidney injury syndromes. This review examines alterations of the renal microvasculature as they relate to ischemic and septic AKI with an emphasis on the mechanisms involved in altered microvascular permeability.

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Acknowledgments

The author is supported by National Institutes of Health (NIH) grants DK-77124 and DK-79312 and a Norman S. Coplon Extramural Research Grant from Satellite Healthcare.

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