Elsevier

Materials Science and Engineering: C

Volume 45, 1 December 2014, Pages 21-28
Materials Science and Engineering: C

Electrochemical behavior and voltammetric determination of acetaminophen based on glassy carbon electrodes modified with poly(4-aminobenzoic acid)/electrochemically reduced graphene oxide composite films

https://doi.org/10.1016/j.msec.2014.08.067Get rights and content

Highlights

  • The 4-ABA/ERGO/GCE was fabricated by a two-step electrochemical method.

  • Electrochemical behavior of acetaminophen at the 4-ABA/ERGO/GCE was investigated.

  • The electrochemical sensor exhibited a low detection limit and good selectivity.

  • This sensor was applied to the detection of acetaminophen in commercial tablets.

Abstract

Poly(4-aminobenzoic acid)/electrochemically reduced graphene oxide composite film modified glassy carbon electrodes (4-ABA/ERGO/GCEs) were fabricated by a two-step electrochemical method. The electrochemical behavior of acetaminophen at the modified electrode was investigated by means of cyclic voltammetry. The results indicated that 4-ABA/ERGO composite films possessed excellent electrocatalytic activity towards the oxidation of acetaminophen. The electrochemical reaction of acetaminophen at 4-ABA/ERGO/GCE is proved to be a surface-controlled process involving the same number of protons and electrons. The voltammetric determination of acetaminophen performed with the 4-ABA/ERGO modified electrode presents a good linearity in the range of 0.1–65 μM with a low detection limit of 0.01 μM (S/N = 3). In the case of using the 4-ABA/ERGO/GCE, acetaminophen and dopamine can be simultaneously determined without mutual interference. Furthermore, the 4-ABA/ERGO/GCE has good reproducibility and stability, and can be used to determine acetaminophen in tablets.

Keywords

Graphene
Poly(4-aminobenzoic acid)
Acetaminophen
Electroanalysis
Voltammetric determination

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