Local antibiotics delivery is an efficient solution to reduce the risk of infections associated with orthopedic implant. This study aims to functionalize plasma-sprayed hydroxyapatite coated titanium (Ti–HA) hip joint implant material with cyclodextrins-polymer (polyCD)-based local drug delivery system for loading therapeutic molecules (e.g. antibiotics), to offer a sustainable drug delivery.
The process of polyCD coating on Ti–HA material was optimized with the help of model guest molecule — toluidine blue O (TBO) for evaluating the efficacy of polyCD system. The obtained results clearly showed that polyCD's treatment can firmly coat on the Ti–HA material under the optimized processing parameters concerning the type of CD, thermal treatment temperature and duration. PolyCD system has been proven to have a high capacity of TBO adsorption and long release duration. In vitro study also showed non-cytotoxicity of polyCD functionalized samples to osteoblastic cells. Trial study with gentamicin revealed very promising potential of polyCD system for sustained delivery of antibiotics. To conclude, the study substantiates the prospective flexibility of drug choice when applying polyCD treated implants including antibiotics, antimitotic agents or other therapeutical molecules. One or more drugs can be loaded, thus synergism and multi-factorial effects are feasible.
Highlights
► Proof-of-concept for polyCD-based drug delivery system on implant for anti-infection ► Long-term release from several days to weeks with pre-determined release rate ► As drug reservoirs to protect from biological and chemical destruction ► Principal compound biocompatible and biodegradable, approved by FDA ► Flexible adsorption by polyCD system to use different therapeutic molecules
