Molecular Cell
Volume 39, Issue 2, 30 July 2010, Pages 171-183
ArticleActivation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
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Graphical Abstract
Highlights
► Unbiased genomic and metabolomic approaches to reveal downstream functions of mTORC1 ► mTORC1 stimulates glucose uptake and glycolysis through HIF1 ► mTORC1 stimulates the pentose phosphate pathway and lipid biosynthesis through SREBP1 ► S6K1 regulates SREBP1 processing and transcriptional activation of target genes
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Cited by (0)
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These authors contributed equally to this work
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These authors contributed equally to this work
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Present address: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
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Present address: Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
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