Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster
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Highlights
► Four PcG binding sites were tested for autonomous PRE activity. ► Two have classical PRE activity. ► One has an unusual downregulating activity and inverse dependence on PC. ► Deletion of one binding site causes a weak derepression. ► A presumptive insulator prevents silencing of flanking genes.
Keywords
Polycomb autoregulation
Polycomb response elements
PcG proteins
Silencing
H3K27 trimethylation
Insulators
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- 1
Present address: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
- 2
Present address: Department of Molecular Biology, Umeå University, Byggnad 6L, 901 87 Umeå, Sweden.
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