Elsevier

Microbes and Infection

Volume 11, Issue 5, April 2009, Pages 612-619
Microbes and Infection

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The calcium/NFAT pathway: role in development and function of regulatory T cells

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Abstract

Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca2+ entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca2+/calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells.

Keywords

Calcium
Foxp3
Stim1

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1

Current address: Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8569, Japan. Tel.: +81 3 5803 5434; fax: +81 3 5803 0193.