F2 isoprostane is already increased at the onset of type 1 diabetes mellitus: Effect of glycemic control
Section snippets
Materials and methods
We studied 14 type 1 diabetic patients recruited from an adult Diabetes Unit at the onset of the disease (50% males; mean age, 24.3 ± 4.9 years) and 14 healthy volunteers (42% males; mean age, 27.4 ± 3.5). The 2 groups were matched with respect to age and body mass index. All patients were nonsmokers and were normotensive (<130/80 mm Hg). Diagnosis of type 1 diabetes was achieved according to the National Diabetes Data Group criteria.7 Patients were excluded if, at admission, they presented
Results
Fourteen patients who fulfilled inclusion criteria were evaluated. At admission all patients presented hyperglycemia and 10 ketonuria. All patients showed autoantibodies related to type 1 diabetes, 83% of which were anti-GAD+ and 66% were IA2+. No differences were noted in any clinical variable evaluated between type 1 diabetic patients and control subjects. In relation to control subjects, urinary 8-epi-PGF2α excretion was significantly higher in type 1 diabetics (66.9 ± 28.9 v 39.1 ± 13.8
Discussion
At present, numerous data support the concept that LP, a marker of OS, is enhanced in diabetes mellitus.1, 2, 3, 4, 5 However, some studies have shown controversial results, probably related to shortcomings in the methods used, because most studies use indirect measurements of LP including susceptibility of LDL to in vitro oxidation or malondialdehyde determination, techniques which are not very specific or accurate.8 F2-isoprostanes are produced in vivo by cycloxygenase-independent free
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2010, Journal of Diabetes and its ComplicationsCitation Excerpt :Evidence has suggested that oxidative stress (OS) may play a role in the pathogenesis of diabetic complications, although the relationship between hyperglycemia and OS is inconsistent in diabetic clinical studies. Statistically significant reduction in 8-epi-PGF(2 alpha) values has been demonstrated in patients with type 1 diabetes upon improvement in metabolic control (Flores, Rodela, Abian, Claria, & Esmatjes, 2004). However, the rise in isoprostane levels was not statistically significant in our study.