Original ArticleAssociation of Plasma Brain Natriuretic Peptide Levels in Acute Ischemic Stroke Subtypes and Outcome
Section snippets
Material and Methods
We prospectively recruited 270 patients with acute ischemic stroke (within 48 hours of symptom onset), admitted to the stroke unit at Yashoda Hospital, a tertiary care center in South India. Another 110 age- and sex-matched controls were recruited from the outpatient clinics. The study was conducted between April 2011 and March 2013. Institutional ethics committee approved this study.
Stroke was defined according to World Health organization as “rapidly developing clinical signs of focal/global
Results
A total of 270 acute stroke patients and 110 control subjects were included in the study. Men constituted 69.6% of stroke patients and 70% of control subjects. Median age was similar in both groups (59 years in stroke patients and 58 years in control subjects). Stroke patients had significantly higher proportion of elevated BNP levels (P < .0001), hypertension (P < .0001), atrial fibrillation (AF; P = .0004), mean serum white blood cell count (P < .0001), and diabetes mellitus (P = .04).
Discussion
We found that increased plasma BNP (>100 pg/mL) levels were observed more commonly in acute ischemic stroke patients (44%) compared with control subjects (3.6%). Elevated BNP level was found as an independent predictor of acute ischemic stroke.
Our findings are in accordance to the previous reports.11, 19, 20 Yukiiri et al21 reported elevated BNP values (>77 pg/mL) in three fourths of their stroke patients. Furthermore, a strong association has been described between high plasma BNP levels and
Conclusions
Our study found that BNP is a reliable marker for the diagnosis and prognostication of cardioembolic stroke in Indian patients. Further larger multicentric studies including various ethnic groups are required to establish the potential role of these findings in stroke management.
Acknowledgments
We are thankful to Dr. G.S. Rao, Managing Director and Dr. A. Lingaih, Director of Medical services, Yashoda group of Hospitals for their generous support to carry out this study in Yashoda Hospital, Hyderabad, India.
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The authors have no conflicts of interest or disclosures to make.