Original ArticleBasal Ganglia Cerebral Microbleeds and Global Cognitive Function: The Kashima Scan Study
Section snippets
Subjects
This is a cross-sectional study based on the Kashima Scan Study, an ongoing population-based cohort study investigating age-related brain changes on MRI.6, 10, 16 A total of 1739 consecutive adults, who underwent health-screening tests of the brain in our center at their own expense between December 2005 and November 2011, were considered for this study. Inclusion criteria were: (1) 20 years of age or older; (2) no disability in instrumental activities of daily living; (3) ability to
Results
In total, 244 CMBs (range, 0-26) were detected in 116 of 1451 subjects (8.0%). A total of 113 CMBs were located in lobar areas. A total of 131 CMBs were located in D/I areas (D/I CMBs were the most common in the BG [58 CMBs]). Of the 116 subjects with CMBs, 43 (3%) were classified in the strictly lobar CMBs group and 73 (5%) in the D/I CMBs group, which composed of the following subgroups (Fig 1: BG group, n = 33; thalamus group, n = 14; infratentorial group, n = 10; other deep areas group,
Discussion
In our ongoing population-based Kashima Scan Study, we have previously demonstrated an association between global cognitive dysfunction and CMBs,6 especially D/I CMBs,10 in Japanese adults, living independently, with no history of neurological disorder, and normal results in neurological examination. Our present cross-sectional study further expands these findings as it demonstrates that BG CMBs (but not thalamic or infratentorial CMBs) are significantly associated with global cognitive
Acknowledgments
We wish to thank Ms. Mai Miyamoto, Dr. Hirotsu Tatsumi, Dr. Junko Nakashima, Dr. Masamichi Oda, and the medical staff of Yuai-Kai Oda Hospital for their help in conducting medical interviews, acquiring clinical data, and inputting data.
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The Kashima Scan Study was partially supported by a Grant-in-Aid for University Reform 2006 from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
The authors declare that there are no conflicts of interest.