The Journal of Steroid Biochemistry and Molecular Biology
Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)☆
Section snippets
Peripheral tissues
The molecular mechanisms underlying insulin resistance in peripheral tissues in PCOS remain under intensive investigation. Fibroblast cultures have been used in an attempt to exclude environmental factors influencing the insulin action in them. The number and the affinity of the insulin receptors have been found normal in adipose tissue, both [13], [14], [15] in muscle [16], [17] and fibroblast cells [18], [19] from PCOS patients. Isolated adipocytes from PCOS women showed a significant
Ovaries
Cholesterol is the universal substrate for steroid biosynthesis. LDL is the major source of cholesterol in humans and is transported into ovarian cells via the LDL receptor pathway [27]. It has been found that in cultures of granulosa cells, gonadotrophins stimulate LDL receptor protein and gene expression [28], [29], [30]. Interestingly, insulin adds to this action of LH and FSH [31]. It is noteworthy to clarify the mediatory role of LH and insulin to the regulation of LDL receptor gene
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Cited by (0)
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Presented at the ‘12th International Congress on Hormonal Steroids and Hormones & Cancer’ (Athens, Greece, 13–16 September 2006).