Original ArticlesCongenital Heart Disease in Premature Infants 25-32 Weeks' Gestational Age
Section snippets
Methods
We performed a retrospective cohort study using the 2003, 2006, 2009, and 2012 Healthcare Cost and Utilization Project Kids' Inpatient Database (KID). The KID is the largest publicly available all-payer pediatric inpatient database and includes approximately 7 million estimated hospitalizations in community, academic, and private hospitals in 44 states. It is a 20% stratified sample of discharges for patients younger than 21 years across the country collected by the Agency for Healthcare
Results
An estimated 249 011 infants were born between 25 and 32 weeks GA, of which 28 806 (116 per 1000 birth hospitalizations of very/extremely premature infants) had CHDs. Of those infants with CHDs, 48.6% were female and 5.9% were SGA (Table III).
Table IV summarizes the birth prevalence of various CHDs. Atrial septal defects (ASDs) were the most commonly diagnosed defect followed by ventricular septal defects (VSDs) andpulmonary stenosis. Severe CHDs had an aggregate birth prevalence of 7.4 (95% CI
Discussion
In this analysis of very and extremely premature infants born 25-32 weeks GA, the overall birth prevalence of CHDs (116/1000 births of similar GA) was significantly higher than the reported birth prevalence of CHDs in term neonates (6-10/1000 births).1, 2, 3, 4, 5 Importantly, the subset of severe CHDs were almost 5-fold more likely in very/extremely premature neonates when compared with term neonates, and very/extremely premature neonates with severe CHDs had a more than 7-fold increased odds
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Supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (1TL1TR001116 [to P.C.] and UL1TR001117 [to J.L., C.H., K.H.]). K.H. receives funding from the Gilead Cardiovascular Scholars Research Program and is a consultant for Kowa Pharmaceuticals. The other authors declare no conflicts of interest.