Surgical oncology and reconstructionPhosphorylated Epidermal Growth Factor Receptor Expression Is Associated With Clinicopathologic Parameters and Patient Survival in Mobile Tongue Squamous Cell Carcinoma
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Patients
The present study was a cohort study of 48 patients with mobile tongue SCC initially treated from 2000 to 2009 at the Department of Otorhinolaryngology-Head and Neck Surgery, Institute Curie, Paris, France. All included patients provided informed consent for use of their biologic samples and clinical data for research purposes. The institutional ethical committee approved the present study. All the patients had undergone initial partial glossectomy as primary treatment, and 39 patients had also
Results
Of the total 48 patients included in the present cohort study, 25 were men and 23 were women, with male/female ratio of 1.09. The patients' age at diagnosis ranged from 33 to 94 years (median age 60, interquartile range [IQR] 53 to 72). The clinicopathologic characteristics of the study sample are presented in Table 1. The patients were followed for 2 to 116 months (median 40, IQR 13 to 66). At the last follow-up visit, 15 patients (31.25%) had died of disease, 3 (6.25%) were alive with
Discussion
EGFR has been implicated in various human malignancies, including oral cancers, because it regulates many cellular functions, such as cell proliferation and survival, that are crucial for tumor development and progression.14 Of even more significance is that several drugs have recently been developed to target the tyrosine domain of EGFR as an approach in cancer treatment.15 Nevertheless, apart from the gradually increasing research in various human malignancies, no comprehensive data are
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Conflict of Interest Disclosures: None of the authors have any relevant financial relationship(s) with a commercial interest.