Review ArticleAssociation between Systemic Diseases and Apical Periodontitis
Section snippets
Materials and Methods
The protocol for this systematic review was developed following established guidelines (21). The protocol was prepared and registered on PROSPERO (registration no. CRD42016034111). Also, a well-defined review question was developed by using the patient population, intervention, comparison, and outcome (PICO) framework.
The AMSTAR checklist, the Oxford Systematic Review Appraisal Sheet, Critical Appraisal Skills Programme, and the Grading of Recommendations Assessment, Development and Evaluation
Results
Because of the heterogeneity among the different studies, it was not possible to perform meta-analysis. Figure 1 presents a flowchart of the systematic review process according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Sixteen articles met the inclusion criteria.
In the present review, 8 of the included studies assessed the association between endodontic pathosis and cardiovascular disease (CVD), 5 studies focused on the association between
Discussion
Our review focused on any associations between endodontic pathosis and 5 primary systemic diseases: CVD, DM, liver, hematology disorder(s), and bone mineral density.
Acknowledgments
The authors deny any conflicts of interest related to this study.
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