In one-dimensional case, various important, weighted polynomial inequalities, such as Bernstein, Marcinkiewicz–Zygmund, Nikolskii, Schur, Remez, etc., have been proved under the doubling condition or the slightly stronger A_∞ condition on the weights by Mastroianni and Totik in a recent paper [G. Mastroianni, V. Totik, Weighted polynomial inequalities with doubling and A_∞ weights, Constr. Approx. 16 (1) (2000) 37–71]. The main purpose of this paper is to prove multivariate analogues of these results. We establish analogous weighted polynomial inequalities on some multivariate domains, such as the unit sphere , the unit ball B^d, and the general compact symmetric spaces of rank one. Moreover, positive cubature formulae based on function values at scattered sites are established with respect to the doubling weights on these multivariate domains. Some of these multi-dimensional results are new even in the unweighted case. Our proofs are based on the investigation of a new maximal function for spherical polynomials.