Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: Part II
Introduction
In spite of tremendous strides in modern medicine, there are hardly any drugs that stimulate liver function, offer protection to the liver from damage or help regeneration of hepatic cells. There are however, a number of drugs employed in traditional system of medicine for liver affections. Many formulations containing herbal extracts are sold in the Indian market for liver disorders. But management of liver disorders by a simple and precise herbal drug is still an intriguing problem.
Azadirachta indica (Meliaceae; Neem) has great reputation in Ayurvedic medicine for treatment of liver disorders. No scientific and methodical investigations have so far been reported in literature regarding its action on liver. Studies conducted in our laboratory reveals that water soluble portion of alcoholic extract of leaves of Azadirachta indica possesses significant antihyperglycemic, antiserotonin, antiinflammatory, hypotensive, hypolipidemic and antifertility activity (Chattopadhyay et al., 1986, Chattopadhyay et al., 1987a, Chattopadhyay et al., 1987b; Chattopadhyay, 1993, Chattopadhyay, 1995, Chattopadhyay, 1997) and also have significant hepatoprotective activity against paracetamol induced hepatic damage in rats (Chattopadhyay et al., 1992). The present investigation has therefore been designed to study the effect of Azadirachta indica leaf extract on other biochemical parameters against paracetamol induced hepatic damage in rats with a view to elucidate possible mechanism behind its hepatoprotective action.
Section snippets
Collection of plant material
Fresh matured leaves of Azadirachta indica were collected from our Institute’s (Indian Statistical Institute, Kolkata, India) garden and were identified by a pharmacognosy expert. At the time of collection standard herbarium record sheets were completed with the name of the collector, collection number, specimen number, locality and local name.
Extraction of plant material
Air-dried powder (1 kg) of Azadirachta indica leaves were extracted by percolation at room temperature with 70% EtOH. Leaf extract of Azadirachta indica
Acknowledgements
Author wishes to acknowledge Professor M. Bandyopadhyay, Head, Department of Pharmacology, SSKM Hospital and Post Graduate Medical Institute, Kolkata and Professor G. Podder, Head, Department of Chemistry, School of Tropical Medicine, Kolkata for their co-operation and help during this work.
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