Letter to the EditorGenetic diversity of human adenovirus in hospitalized children with severe acute lower respiratory infections in Paraguay
Section snippets
Funding
This work was funded in part by a fellowship to Daniel Benítez from the Consejo Nacional de Ciencia y Tecnología (CONACyT), Paraguay.
Competing interests
There are no competing interests.
Ethical approval
This protocol was approved by the Ethical Committee of the Instituto de Investigaciones en Ciencias de la Salud, under the following number: C45/2011.
Acknowledgements
We would like to thank Dr. Angilberto Paredes and Dr. Pio Alfieri (Directors of the Hospital General Pediátrico Niños de Acosta Ñu), and the following personnel from this institution: Dra. Viviana Pavlicich, Dra. Gloria Martínez, Dra. Carlos Caballero, Dra. Amalia Duarte, Dr. Héctor Castro, and Dr. Carolina Aquino, for the encouragement and support throughout the study.
References (13)
- et al.
Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality
Virology
(2011) - et al.
Adenovirus
Semin Respir Crit Care Med
(2011) Adenoviruses
- et al.
Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy
J Virol
(2005) - et al.
The role of adenovirus in respiratory tract infections
Curr Infect Dis Rep
(2010) - et al.
Rapid and simple method for purification of nucleic acids
J Clin Microbiol
(1990)
Cited by (5)
Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection
2014, Jornal de PediatriaCitation Excerpt :In São Paulo, Brazil, Thomazelli et al.21 reported an overall positivity rate of 55.6% (187/336), with RSV in 24.1% and ADV in 6.8% of cases investigated by PCR for some of the same eight respiratory viruses analyzed in the present study, but in children up to 5 years of age hospitalized for suspected ARI. The high positivity for ADV observed in the present study could be the result of a convergence of different factors: the large number of hospitalized cases included, perhaps due to a broader range of acceptable diagnoses as inclusion criteria; the younger age group, likely to coincide with a peak incidence of disease associated with ADV;7,8,19 or the exclusive analysis of NPA samples collected in the first 24 hours of admission, which contain higher viral titers. ADV screening test by qualitative PCR is difficult to interpret, as it does not necessarily indicate it as the causative agent of the disease under investigation.
Clinical Characteristics and Genotyping of Pediatric Adenovirus Pneumonia Disease and Coinfection in Southeast China
2023, Genetic Testing and Molecular BiomarkersAdenoviruses: Biology and epidemiology
2017, Human Virology in Latin America: From Biology to ControlDetection of adenovirus infection among children with acute respiratory disease during 2010-2012 in Shiraz, Iran
2014, Archives of Pediatric Infectious Diseases