NOTEQuantitative correlation between production rate of melanoma inhibitory activity and aggrecan gene expression level during differentiation from mesenchymal stem cells to chondrocytes and redifferentiation of chondrocytes
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Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice
2014, Mechanisms of DevelopmentCitation Excerpt :The MIA/CD-RAP expression correlates tightly with the expression of cartilage specific collagen type II (Dietz and Sandell, 1996). Differentiation of human mesenchymal stem cells and re-differentiation of primary chondrocytes showed co-expression of MIA/CD-RAP with the major cartilage component aggrecan (Onoue et al., 2011). In vivo experiments, using transgenic mice in which the lacZ-reporter gene was under the control of the MIA/CD-RAP promoter, showed restricted expression of the reporter gene in developing chondrocytes and in mature cartilage (Xie et al., 2000).
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