LetterThe EuroSCAR study: Cannot agree with the conclusions
References (6)
- et al.
Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective study on patients included in the prospective EuroSCAR study
J Am Acad Dermatol
(2008) - et al.
Toxic epidermal necrolysis: does immunoglobulin make a difference?
J Burn Care Rehabil
(2004) - et al.
Intravenous immunoglobulin treatment for Stevens–Johnson syndrome and toxic epidermal necrolysis
Arch Dermatol
(2003)
Cited by (7)
Intravenous Immunoglobulin Therapy
2020, Comprehensive Dermatologic Drug Therapy, Fourth EditionEpidermal necrolysis: SCORTEN performance in AIDS and non-AIDS patients
2019, Anais Brasileiros de DermatologiaCitation Excerpt :The severity of such events imposes the significance of adequate management. Corticotherapy,8,9 intravenous immunoglobulin therapy,10,11 and cyclosporine-A12 have been proposed as treatments; however, there is still no consensus or guidelines about their use, nor satisfactory treatment trials to further evaluate the true impact of such therapies.4,8,13,14 Bastuji-Garin et al analyzed French patients diagnosed with EN and proposed a score to determine prognosis: the SCORTEN.15 (
Toxic epidermal necrolysis: Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment
2013, Journal of the American Academy of DermatologyCitation Excerpt :Previous studies showing a beneficial effect of IVIG may have been biased by the reliance on physicians’ assessment of area of skin detachment, which is often overestimated, and by the lack of control groups for comparison.108 However, the total dose of IVIG administered in the aforementioned retrospective analysis was lower than that of the previous studies reporting a mortality benefit.109 In another retrospective study, 23 patients treated with a total dose of 2.8 g/kg of IVIG plus 1 g per day of corticosteroids were found to have no significant difference in mortality compared with that predicted by SCORTEN.
Intravenous immunoglobulin therapy
2012, Comprehensive Dermatologic Drug Therapy: Expert Consult - Online and PrintDirect Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease
2021, Ophthalmic Plastic and Reconstructive SurgeryDrug induced exfoliative dermatitis: State of the art
2016, Clinical and Molecular Allergy
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