International Journal of Radiation Oncology*Biology*Physics
Poster Viewing PresentationProspective Evaluation of Gastrointestinal (GI) and Genitourinary (GU) Toxicity of Salvage Radiotherapy (RT) to the Prostate Bed for Patients with PSA Relapse after Radical Prostatectomy (RP)
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Purpose/Objective(s)
To evaluate acute and late toxicity of salvage RT to the prostate bed for patients with PSA relapse after RP.
Materials/Methods
A total of 75 patients were accrued between 1998 and 2002 for a Phase II study to evaluate the efficacy of a combined, sequential, treatment of salvage RT plus 2-year androgen suppression (LHRH analogue) for patients with PSA relapse after RP. Clinical target volume of RT was limited to the prostate bed. A total dose of 60-66 Gy (2 Gy/fraction) was delivered with a 4-field box technique, using 18 MV photons. Acute and late RT morbidity was prospectively assessed, using the NCI Expanded Common
Results
Median age was 63 years at the time of RP. Median time from RP to RT was 36.2 months. As of 3/2005, median follow-up was 45.1 months. 75 and 72 patients were available for acute and late toxicity analysis, respectively. 12% and 40% had pre-existing GI and GU dysfunction prior to RT, respectively. Acute toxicity was common, but mild (GI toxicity: 71%, 11%, and 3% for Grade 1, and 2, and 3, respectively; GU toxicity: 71%, 9%, and 3% for Grade 1, 2, and 3, respectively). 5% experienced Grade 3
Conclusions
Salvage RT for PSA relapse after RP was generally well tolerated. Grade ≥3 late GI or GU toxicity was uncommon.
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Author Disclosure: M. Pearse, None; R. Choo, None; C. Danjoux, None; S. Gardner, None; G. Morton, None; E. Szumacher, None; A. Loblaw, None; P. Cheung, None.