NoteTaste acceptability of pulverized brand-name and generic drugs containing amlodipine or candesartan
Graphical abstract
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Cited by (3)
Acceptability of generic versus innovator oral medicines: not only a matter of taste
2021, Drug Discovery TodayModified β-cyclodextrin/amlodipine inclusion complexes: Preparation and application in aqueous systems
2019, Journal of Molecular LiquidsCitation Excerpt :The half-life of plasma terminal elimination is about 35 to 50 h, which defines a more efficient administration as a single daily dose. The level of plasma stability is achieved 7 to 8 days after the initial dose [23,24]. It is mentioned in the literature that the amlodipine degrades in the presence of light, thus precautions are advisable in the therapeutic application of this drug.
Coated dextrin microcapsules of amlodipine incorporable into orally disintegrating tablets for geriatric patients
2014, Biomedicine and PharmacotherapyCitation Excerpt :The approach is supported by gelatin or dextrin-based microencapsulation used to improve the oral bioavailabilty of poorly water soluble drugs [18–21]. Amlodipine also has a bitter taste, which may lead to poor medication adherence [22,23]. Encapsulation of bitter or unpleasant tasting agents into microcapsules or microspheres prepared with aminoalkyl methacrylate copolymers effectively masks taste and is potentially applicable to ODT's [24–27].