International Journal of Oral and Maxillofacial Surgery
Research PaperTMJ DisordersInvestigation of an autologous blood treatment strategy for temporomandibular joint hypermobility in a pig model
Section snippets
Materials and methods
12 pigs (Sus scrofa f. domestica) aged 2 years were obtained from the breeding unit of the Institute of Animal Physiology and Genetics, Academy of Science of the Czech Republic in Libechov. Animals were divided into four groups of three animals, none of which had any previous history of TMJ hypermobility. The first group was killed 1 h after treatment, the second group 1 week, the third group 2 weeks and the fourth group 4 weeks after autologous blood injection. The animals were housed in
Results
In the samples taken 1 h and 1 week after treatment, macroscopic examination revealed deposition of the remaining blood in the form of clots in distal parts of the upper joint cavity. No alterations on the articular surface were observed. 2 weeks after treatment, small blood clots were still apparent in the distal part of the upper joint cavity. 4 weeks after surgery, no remnants of blood, changes or adhesions were apparent inside the TMJ (Fig. 2).
In MRI, the injection injury caused by the
Discussion
Autologous blood injection is a simple treatment for TMJ hypermobility in humans. The major advantage of TMJ autologous blood injection is that it is minimally invasive, and being a non-surgical technique it is more acceptable and comfortable for patients. This method does not require surgical incision, tissue dissection, bone preparation or general anaesthesia, and eliminates postoperative complications such as facial nerve injuries, infection and oedema. The disadvantages of the technique are
Funding
This study was funded by Ministry of Education, Youth and Sport of the CR (Project FRVS G4l455l2008) and SVC 1M0528 Craniofacial Medical Research using animal models runs under the project of the Ministry of Health (OK 10/ll – NT 1 1420-612010).
Competing interests
The authors report no conflicts of interest.
Ethical approval
The experimental procedure was approved by the Animal Research Committee of IAPG CAS, v.v.i. (Nr. 67985904).
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