Original clinical scienceTroponin I levels from donors accepted for pediatric heart transplantation do not predict recipient graft survival
Section snippets
Data collection and study population
The United Network for Organ Sharing (UNOS) provided deidentified data for the 847 heart transplants, which took place between April 1, 2007, and April 30, 2009 in recipients aged ≤ 21 years old. Follow-up was current through December 11, 2009. Within this period, 8 recipients received 2 transplants, and the second transplant was excluded from analysis. The troponin I levels recorded in this data set represent the last available troponin I level reported to UNOS from a donor before
Results
Of 839 heart transplants analyzed in recipients aged ≤ 21 years old, a troponin I value was recorded from the donor before organ procurement in 657. Overall graft survival at 2 years was 81%. There was no difference in graft status between those with and those without a measured donor troponin I level (p = 0.75). For those with a donor troponin I measurement, there was no correlation between donor troponin I level and graft status (p = 0.74; Figure 1). The troponin I level was ≥ 1 ng/ml in 74
Discussion
In this retrospective analysis of all pediatric heart transplant recipients in the UNOS data registry for whom there are recorded donor cardiac troponin I levels from April 2007 to April 2009, no correlation was found between donor troponin I levels and graft survival after transplantation. Indeed, grafts from donors with even the highest pre-procurement troponin I levels demonstrated survivability on par with the rest of the data set. In addition, we demonstrate that donor pre-procurement
Disclosure statement
This work was supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the
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Assessment of potential heart donors: A statement from the French heart transplant community
2018, Archives of Cardiovascular DiseasesCitation Excerpt :A few studies have investigated the potential prognostic impact of donor troponin concentrations on recipient outcome, and have reported conflicting results (Table 10). Preliminary studies suggested a negative impact of elevated donor troponin concentrations on graft function [74–79], but this was not confirmed in more recent studies conducted on larger populations [80–84]. The marked heterogeneity of the troponin assay methods used and the populations included in these studies should be stressed.
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